If you have read my post on how does distortion work you already understand the physics: signal clipping, harmonic saturation, the difference between soft and hard clipping, why even-order harmonics sound warm and odd-order harmonics sound harsh. This post is the practical companion to that one. Not what distortion is doing to the signal but how to make decisions about when to use it, how much to use, and when to put it down entirely.
The honest answer to how to use distortion is that most people are using too much of it. I see this in mixes I listen to critically and I have done it myself at various points. The instinct when you are excited about a tone is to push it further. Distortion has a way of sounding bigger and more exciting in isolation that evaporates the moment everything else comes back in the mix. What felt like the right amount alone almost always turns out to be too much in context.
I am Tony Oso, a rock and alternative artist and electrical engineer from Melbourne, Florida. Here is my actual approach.

The Question Before the Decision
Before I reach for any distortion I ask one question: does this section need more edge or is this section not working for a different reason?
Most of the time when a mix or a part feels flat the instinct is to add distortion because distortion creates the impression of energy. But that impression is often covering the actual problem rather than solving it. A guitar part that is too loud in the mix will feel aggressive rather than energetic and adding distortion makes it louder and more aggressive rather than actually energetic. A vocal that is not connecting emotionally will not connect more with saturation on it. A chorus that does not lift will not lift with a heavier guitar tone if the arrangement is not creating the lift.
Distortion should be the answer to a specific question: does this part need more harmonic richness and grit to do what it needs to do emotionally? If the answer is yes, use it. If the answer is something else, solve that something else first.
On Guitar
I start clean or with just a hint of breakup and work upward from there. The reason for this is that it is much easier to hear when you have found the right amount of distortion if you arrive there from the clean side than if you arrive there from the heavy side by pulling back. Starting heavy and reducing means you are trying to find where the distortion stops being a problem. Starting clean and adding means you are trying to find where the distortion starts contributing. Those are different listening tasks and the second one produces better decisions.
For most of my rhythm guitar work the goal is controlled grit rather than saturation. I want the harmonic texture that distortion provides without the compression and loss of note definition that comes from too much gain. The notes need to be audible as individual notes in the arrangement even when strumming chords. Heavy distortion compresses the dynamics between notes in a way that reduces that definition.
The chorus lift is the most common place where more distortion is genuinely the right answer. A clean verse into a distorted chorus creates contrast that the ear reads as energetic and forward-moving. But the distortion in the chorus only works as a lift if the verse was actually clean. If both sections are distorted the chorus has nowhere to go and the contrast disappears.
Layering is also a technique worth understanding. Blending a distorted guitar track underneath a clean one gives you the harmonic richness and body of distortion without losing the attack and definition of the clean signal. The clean track provides clarity. The distorted track provides texture. Combined they produce something that sits well in a mix better than either approach alone.
On Vocals
I use distortion and saturation on vocals rarely and with significant caution. The reasons are connected to what I wrote about in my reverb post: the voice is the emotional center of most songs and anything that adds distance between the listener and the vocal performance is working against the song's primary purpose.
Saturation on a vocal adds harmonic warmth in a way that can be genuinely useful if the recording is thin or if the emotional character of the song calls for a rougher texture. I have used it on sections where the lyric needed a rawer, more desperate quality and the saturation gave the vocal an edge that matched the emotional register.
The test I apply is simple: if you can hear the distortion or saturation clearly on its own, it is probably too much. The effect should be audible in comparison to the unprocessed version but not immediately identifiable as a processed effect when listened to in context. If someone listening to the finished song thinks the vocal sounds gritty before they think about why, the effect is too heavy.
On the Mix Bus
Subtle analog-style saturation on the mix bus is a legitimate technique for adding warmth and cohesion to a mix. The operative word is subtle. What I am looking for from mix bus saturation is the quality of the mix changing slightly in character, becoming slightly warmer and more unified, not the quality of a distorted sound being added to the mix.
The test is identical to the vocal test. If you can clearly hear the saturation as an effect, pull it back. If toggling it on and off reveals a slight but meaningful improvement in warmth and cohesion, you have found the right level. If the difference is dramatic, you have too much.
This is connected to the broader argument I made in my compression post about the tendency to over-process in modern production. Saturation at the mix bus level is doing similar work to light bus compression: adding subtle glue without the listener being aware of the processing. Both work best when they are invisible.
The Practical Rules
Start clean and add distortion only when you have identified what it is adding. The burden of proof should be on the distortion rather than on the clean signal.
Use distortion for contrast. A distorted element hits harder when it is surrounded by cleaner elements. If everything is distorted the distortion loses its impact because there is nothing to contrast it against.
Check everything in context. The solo guitar that sounded perfect with the gain turned up will almost always need to come back down when the bass, drums, and vocals are playing alongside it. Make all final distortion decisions with the full mix playing.
Trust quiet more than you think you should. Some of the most effective distortion in recordings is barely audible as distortion but is providing harmonic texture that you would notice immediately if it were removed. Less is often more in ways that are not obvious until you actually compare.
For the technical explanation of what distortion is doing to the waveform when you make these decisions, my post on how does distortion work covers the physics in depth, including the difference between soft and hard clipping and why different distortion types have different tonal characters. Understanding the mechanism helps you make better decisions about the application.
And for how I EQ guitar signals both before and after distortion to control which frequencies get the most harmonic saturation, the guitar EQ cheat sheet covers that territory with the specific frequency ranges that matter most.